Analysis of platinum content in biodegradable carboplatin-impregnated beads and retrospective assessment of tolerability for intralesional use of the beads in dogs following excision of subcutaneous sarcomas: 29 cases (2011-2014)

作者：Hess Theresa A; Drinkhouse Macy E; Prey Joshua D; Miller Jonathan M; Fettig Arthur A; Carberry Carol A; Brenn Stephen H; Bailey Dennis B^*

来源：Journal of the American Veterinary Medical Association, 2018, 252(4): 448-456.

DOI：10.2460/javma.252.4.448

OBJECTIVE
To evaluate platinum content in biodegradable carboplatin-impregnated beads and retrospectively assess tolerability and outcome data for dogs treated by intralesional placement of such beads following surgical excision of subcutaneous sarcomas.
DESIGN
Evaluation study and retrospective case series.
SAMPLE
9 carboplatin-impregnated beads and 29 client-owned dogs.
PROCEDURES
Platinum content in 9 carboplatin-impregnated beads from 3 lots was measured by spectrophotometry, and calculated carboplatin content was compared with the labeled content. Medical records were searched to identify dogs with subcutaneous sarcomas for which treatment included placement of carboplatin-impregnated beads between 2011 and 2014. Signalment, tumor characteristics, surgical and histologic data, adverse events, and local recurrences were recorded. Associations between variables of interest and adverse events or local disease-free interval were analyzed.
RESULTS
In vitro analysis identified a mean +/- SD platinum content of 5.38 +/- 0.97 mg/bead. Calculated carboplatin content (10.24 +/- 1.84 mg/bead) was significantly greater than the labeled amount (4.6 mg/bead). Bead weight and total platinum content differed significantly among lots, but platinum content per bead weight did not. Mild-to-moderate local adverse events were reported for 11 of 29 tumors; all resolved without additional surgery. No dogs had signs of systemic toxicosis. Overall local disease-free rates 1, 2, and 3 years after surgery were 70%, 70%, and 58%, respectively, as determined by Kaplan-Meier analysis.
CONCLUSIONS AND CLINICAL RELEVANCE
Carboplatin-impregnated beads were well tolerated; however, results of in vitro tests indicated that caution is needed because of manufacturing inconsistencies.

• 出版日期2018-2-15