Ultrastable Artificial Binding Pairs as a Supramolecular Latching System: A Next Generation Chemical Tool for Proteomics

作者:Park Kyeng Min; Murray James; Kim Kimoon*
来源:Accounts of Chemical Research, 2017, 50(3): 644-646.
DOI:10.1021/acs.accounts.6b00645

摘要

In this Commentary, we discuss cucurbit[7]uril-based ultrastable artificial binding pairs as a supramolecular latching system and how we envision this becoming important tools in proteomics. The limitations of current proteomic techniques are described with an emphasis on the lack of tools to answer questions about the complex and dynamic nature of the proteome. Our thoughts as to how artificial ultrastable binding pairs may be able to address these questions are given especially when they are combined with existing methods.

  • 出版日期2017-3