Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice

作者：Dun Linglu; Li Yuxiang; Xu Yaqiong; Zhou Ru; Ma Lin; Jin Shaoju; Du Juan; Sun Tao; Yu Jianqiang^*

来源：Neurological Sciences, 2014, 35(6): 815-821.

DOI：10.1007/s10072-013-1603-6

• Vincristine
• Neuropathic pain
• Matrine
• Antinociceptive

Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 mu g/kg i.p.) was administered once per day for 7 days (day 0-6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0-6) or late phase (day 7-13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain.

• 出版日期2014-6
• 单位宁夏医科大学