A radiation hybrid comparative map of ovine chromosome 1 aligned to the virtual sheep genome

作者：Wu C H; Jin W; Nomura K; Goldammer T; Hadfield T; Dalrymple B P; McWilliam S; Maddox J F; Cockett N E^*

来源：Animal Genetics, 2009, 40(4): 435-455.

DOI：10.1111/j.1365-2052.2009.01857.x

• chromosome
• comparative map
• ovine
• radiation hybrid
• virtual sheep genome

P>Ovis aries chromosome one (OAR1) is the largest submetacentric chromosome in the sheep genome and is homologous to regions on human chromosomes 1, 2, 3 and 21. Using the USUoRH5000 ovine whole-genome radiation hybrid (RH) panel, we have constructed a RH map of OAR1 comprising 102 framework and 75 placed/binned markers across five linkage groups spanning 3759.43 cR5000, with an average marker density of 21.2 cR5000/marker. The alignment of our OAR1 RH map shows good concordance with the recently developed virtual sheep genome, with fewer than 1.86% discrepancies. A comparative map of OAR1 was constructed by examining the location of RH-mapped orthologues in sheep within the genomes of cow, human, horse and dog. Analysis of the comparative map indicates that conserved syntenies within the five ovine RH linkage groups underwent internal chromosomal rearrangements which, in general, reflect the evolutionary distances between sheep and each of these four species. The ovine RH map presented here integrates all available mapping data and includes new genomic information for ovine chromosome 1.

• 出版日期2009-8
• 单位云南大学; CSIRO