A Conducting Polymer/Protein Composite with Bactericidal and Electroactive Properties

作者：Teixeira Dias Bruno; del Valle Luis J; Aradilla David; Estrany Francesc; Aleman Carlos^*

来源：Macromolecular Materials and Engineering, 2012, 297(5): 427-436.

DOI：10.1002/mame.201100172

• bactericidal
• biocomposites
• conducting polymers
• proteins

Lysozyme, an enzyme with bactericidal activity over Gram-positive bacteria cells, is incorporated into PEDOT to prepare films with high biological and electrochemical activity. Two different strategies are used: (1) PEDOT films are coated with a layer of enzyme, which was adsorbed on the surface; and (2) the lysozyme is added to the polymerization medium used for the preparation of the conducting polymer. The enzyme adsorbed at the surface of the polymer produces a biphasic system that retains the electrochemical properties of the conducting polymer but is not able to protect against bacterial growth. In contrast, the addition of lysozyme to the polymerization medium results in a homogeneous composite with high bactericidal and electrochemical activities.

• 出版日期2012-5