Emerging therapies for rheumatoid arthritis

作者：Jacques Peggy; Van den Bosch Filip^*

来源：Expert Opinion on Emerging Drugs, 2013, 18(2): 231-244.

DOI：10.1517/14728214.2013.807339

• biological therapy
• cytokines
• kinase inhibitors
• rheumatoid arthritis

Introduction: With the introduction of biologic therapies, tremendous progress has been made in the treatment of rheumatoid arthritis (RA). However, up to 40% of patients do not respond to these treatments. %26lt;br%26gt;Areas covered: Several new treatment strategies are discussed, with brief overview of currently performed clinical trials. The development of molecules targeting cytokines other than TNF is discussed, as well as chemokine-directed drugs. Finally, the area of small molecular inhibitors is explored. %26lt;br%26gt;Expert opinion: Since RA is a life-long disease often evolving into disability, development of new treatment strategies remains crucial. Especially small molecules targeting JAK, Syk and PDE4 may provide novel therapeutic options.

• 出版日期2013-6