Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicola

作者：Liu Xue Ting; Winkler Abby L; Schwan William R; Volk Thomas J; Rott Marc; Monte Aaron^*

来源：Planta Medica, 2010, 76(5): 464-466.

DOI：10.1055/s-0029-1186227

• antibacterial activity
• Fomitopsis pinicola (Polyporaceae)
• lanostane triterpenoid
• ergostane steroid
• Bacillus cereus

Anti-Bacillus cereus bioassay-guided fractionation of a crude extract of the American mushroom, Fomitopsis pinicola, was performed using thin-layer chromatography, Sephadex LH-20 column chromatography, and preparative-scale HPLC. Five lanostane triterpenoids (1-5) and one ergostane steroid (6) were isolated and identified. Compound 1 is a new lanostane triterpenoid, and its structure was determined using 1D and 2D NMR experiments, HR-MS, and physical data. Each of the purified compounds (1-6) was tested for antibacterial activity against B. cereus using standard MIC assays. Compounds 1-6 had MIC values of 32, 16, 32, 32, 128, and 64 mu g/mL, respectively.

• 出版日期2010-3