Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways

作者：Kim Seok Jai; Jeong Cheol Won; Bae Hong Beom; Kwak Sang Hyun; Son Jong Keun; Seo Chang Seob; Lee Hyun Jung; Lee JongUn; Yoo Kyung Yeon^*

来源：Journal of Korean Medical Science, 2012, 27(5): 572-575.

DOI：10.3346/jkms.2012.27.5.572

• Sauchinone
• Cardioprotection
• Ischemia/reperfusion Injury
• Cell Death Signaling Pathway
• Reperfusion Injury Salvage Kinase Pathway

Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3 beta was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% +/- 5.3% in the sauchinone group vs 44.4% +/- 6.1% in the control, P %26lt; 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3 beta was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways.

• 出版日期2012-5