A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones

作者：Mendez Leticia J; Canepa Alicia S^*; Gloria Gonzalez M; Bravo Rodolfo D

来源：Tetrahedron Letters, 2012, 53(6): 688-690.

DOI：10.1016/j.tetlet.2011.11.128

• 1-Aryl-substituted 2H-isoquinolin-3-ones
• One-pot synthesis
• Sulfated zirconia
• 2-Acylphenylacetonitriles
• Intramolecular cyclization

The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenyl-acetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method.

• 出版日期2012-2-8