ANTIVIRAL PROPERTIES OF THE RECOMBINANT RECEPTOROTOXINS CONSISTING OF DIPHTHERIA-TOXIN AND CD4-RECEPTOR FRAGMENTS

作者：SIDOROV **^*; ZDANOVSKY AG; ZVEREV VV; PUGACH **; MALYUSHOVA VV; ANJAPARIDZE OG

来源：Voprosy Virusologii, 1994, 39(1): 6-10.

A number of vectors expressing in E. coli hybrid proteins (receptorotoxins) composed of diphtheria toxin lacking the C-terminal region and- CD4-receptor fragment including N-terminal region of the natural protein have been constructed. The receptorotoxins consisting of the CD4 fragment in their N-terminal region were more stable. These recombinant receptorotoxins were cultured with HIV-infected Hut-78 cells and were shown to block HIV infection in vitro.

• 出版日期1994-2