An eco-friendly three-component regio- and stereoselective synthesis of highly functionalized dihydroindeno[1,2-b]pyrroles under grinding

作者：Muthusaravanan Sivasubramanian^*; Sasikumar Chinnathambi; Bala Balasubramanian Devi; Perumal Subbu

来源：Green Chemistry, 2014, 16(3): 1297-1304.

DOI：10.1039/c3gc42150c

Facile three-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones with anilines and ninhydrin in an equimolar ratio upon grinding in the presence of acetic acid (0.1 ml per mmol of reactants) afforded highly functionalized dihydroindeno[1,2-b]pyrroles regio- and stereoselectively in good yields. This protocol has advantages such as solvent-free reactions under grinding, ambient temperature, short reaction times, simple work-up avoiding chromatographic purification and excellent yields.

• 出版日期2014