Arterial Indices and Serum Cystatin C Level in Individuals With Occupational Wide Band Noise Exposure

作者：Khoshdel Ali R; Mousavi Asl Benyamin^*; Shekarchi Babak; Amini Kazem; Mirzaii Dizgah Iraj

来源：Noise and Health, 2016, 18(85): 362-367.

DOI：10.4103/1463-1741.195810

• Arterial stiffness
• carotid intima-media thickness
• cystatin C
• noise
• occupational

Background: Chronic exposure to noise is known to cause a wide range of health problems including extracellular matrix (ECM) proliferation and involvement of cardiovascular system. There are a few studies to investigate noise-induced vascular changes using noninvasive methods. In this study we used carotid artery intima-media thickness (CIMT) and aortic augmentation as indices of arterial properties and cystatin C as a serum biomarker relating to ECM metabolism. Materials and Methods: Ninety-three male participants were included in this study from aeronautic technicians: 39 with and 54 without a history of wide band noise (WBN) exposure. For better discrimination, the participants were divided into the two age groups: <40 and >40 years old. Adjusted aortic augmentation index (AI) for a heart rate equal to 75 beats per minute (Alx@HR75) were calculated using pulse wave analysis (PWA). CIMT was measured in 54 participants who accepted to undergo Doppler ultrasonography. Serum cystatin C was also measured. Results: Among younger individuals the mean CIMT was 0.85 +/- 0.09 mm and 0.75 +/- 0.22 mm in the in the exposed and the control groups respectively. Among older individuals CIMT had a mean of 1.04 +/- 0.22 mm vs. 1.00 +/- 0.25 mm for the exposed vs. the control group. However, in both age groups the difference was not significant at the 0.05 level. A comparison of AIx@HR75 between exposure group and control group both in younger age group (5.46 +/- 11.22 vs. 8.56 +/- 8.66) and older age group (17.55 +/- 10.07 vs. 16.61 +/- 5.77) revealed no significant difference. We did not find any significant correlation between CIMT and Alx@HR75 in exposed group (r = 0.314, P value = 0.145) but the correlation was significant in control group (r = 0.455, P value = 0.019). Serum cystatin C level was significantly lower in individuals with WBN exposure compared to controls (441.10 +/- 104.70 ng/L vs. 616.89 +/- 136.14, P value < 0.001) both in younger and older groups. Conclusion: We could not find any evidence for the association of WBN exposure with arterial properties, but cystatin C was significantly lower in the exposed group.

• 出版日期2016-12