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摘要
Substituted enamides were prepared by a three-component reaction of lithiated alkoxyallenes, nitriles, and carboxylic acids. Their subsequent condensation with ammonium salts provided alkoxy-substituted pyrimidine derivatives. This two-step method is highly flexible with respect to the substitution pattern at C-2 and C-6. The C-4 and C-5 positions can smoothly be functionalized employing either Pd-catalyzed couplings or oxidation methods.
- 出版日期2009-4-23
