Glioblastoma with primitive neuronal component: report of a case and review of literature

作者：Liu, Jing^*; Wang, Wei; Zhang, Yongxia; Jiang, Lei; Qu, Guimei; Zhang, Tingguo

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(9): 13458-13462.

• Glioblastoma
• primitive neuronal component
• isocitrate dehydrogenase 1 (IDH1)

According to the 2016 WHO Classification, glioblastoma with primitive neuronal components (GBM-PNC) was added as a pattern in glioblastoma. A 59-year-old woman presented initially with paroxysmal headache at bilateral frontal temporal for a month. Imaging showed a solid cystic mass in the right frontal lobe with a range of 4.7 cmx5.6 cm. She had an operation to excise the occupying lesion in the right frontal lobe. The pathological diagnosis was GBM-PNC by histological and immunohistochemical staining. Also, this case was analyzed for IDH1 (R132) mutation by PCR and pyrosequencing, which showed that it was IDH-wildtype. The prognosis of this type is poor. In addition, literature review was carried out to discuss its clinical manifestation, histological and immunohistochemistry features, differential diagnosis and prognosis.

• 出版日期2017
• 单位山东大学; 青岛大学; 烟台毓璜顶医院