Arginine Regulates the Negative Effect of Intrauterine Growth Retardation by Increasing Mucosal mTOR Signal in Neonatal Pigs

作者：Wang Yuanxiao^*; Zhang Lili; Wang Tian; Xu Ruojun

来源：International Conference on Agricultural and Biosystems Engineering, 2011-02-20 to 2011-02-21.

• IUGR
• Arginine
• small intestine
• mTOR
• neonatal piglets

Intrauterine growth retardation (IUGR) has negative effects on growth and intestinal development of neonatal pigs. L-arginine (Arg), is more deficient in IUGR fetus, plays critical roles in promoting growth and metabolism of neonatal pigs. In this study, normal and IUGR piglets were fed milk-based diets supplemented with 0 and 0.6% Arg respectively from 7(th) to 14(th) d of age. IUGR decreased (P < 0.05) the growth performance, the whole small intestine (SI) weight, as well as the phosphorylated mTOR and S6K1. Arg supplementation increased (P < 0.05) the growth performance, weight of whole SI and mucosa. These changes were associated with increased (P < 0.05) phosphorylated mTOR in small intestinal mucosa of IUGR piglets. These findings suggest that Arg is beneficial in improving the delayed growth and SI growth caused by IUGR. The findings provide an effective way to stimulate the growth of IUGR fetus after birth by dietary supplementation with Arg.

• 出版日期2011
• 单位南京农业大学