Anti-inflammatory Effects of Polihexanide and Polyethylene Glycol in an In Vitro Study in Chronic Rhinosinusitis

作者：Birk Richard^*; Gros**aier Judith; Aderhold Christoph; Stern Straeter Jens; Hoermann Karl; Sauter Alexander; Sommer J Ulrich

来源：In Vivo, 2014, 28(4): 489-494.

• Chronic rhinosinusitis
• polihexanide
• polyethylene glycol
• IL-5
• MMP-9
• eotaxin-3
• anti-inflammatory

The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtaining samples from 10 CRS patients with (CRSwNP) and without nasal-polyposis (CRSsNP) and 2 patients with inverted-papilloma undergoing functional endoscopic sinus surgery (FESS), the expression of interleukin-5, eotaxin-3 and MMP-9 were evaluated by an ELISA assay with and without the tested agent. CRSwNP showed a significantly increased expression of IL-5. Polihexanide seems not to alter the attraction of eosinophils in patients with CRS via IL-5 expression. Also elevated levels of MMP-9 could not be reduced to normal values. But there exists statistically significant evidence that the self-amplification process of eosinophils via eotaxin-3 could be influenced by the administration of polihexanide.

• 出版日期2014-8