Anti-staphylococcal activity and beta-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate

作者：Anderson James C^*; McCarthy Robert A; Paulin Sarah; Taylor Peter W

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(23): 6996-7000.

DOI：10.1016/j.bmcl.2011.09.116

• MRSA
• (-)-Epicatechin gallate analogues
• beta-Lactam antibiotics
• Antibacterial chemotherapy
• Antibiotic resistance

We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (-)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcus aureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.

• 出版日期2011-12-1