Micro-Structural Brain Alterations in Aviremic HIV plus Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field

作者：Granziera Cristina^*; Daducci Alessandro; Simioni Samanta; Cavassini Matthias; Roche Alexis; Meskaldji Djalel; Kober Tobias; Metral Melanie; Calmy Alexandra; Helms Gunther; Hirschel Bernard; Lazeyras Francois; Meuli Reto; Krueger Gunnar; Du Pasquier Renaud A

来源：PLos One, 2013, 8(9): e72547.

DOI：10.1371/journal.pone.0072547

Objective: Mild neurocognitive disorders (MND) affect a subset of HIV+ patients under effective combination antiretroviral therapy (cART). In this study, we used an innovative multi-contrast magnetic resonance imaging (MRI) approach at high-field to assess the presence of micro-structural brain alterations in MND+ patients. %26lt;br%26gt;Methods: We enrolled 17 MND+ and 19 MND- patients with undetectable HIV-1 RNA and 19 healthy controls (HC). MRI acquisitions at 3T included: MP2RAGE for T1 relaxation times, Magnetization Transfer (MT), T2* and Susceptibility Weighted Imaging (SWI) to probe micro-structural integrity and iron deposition in the brain. Statistical analysis used permutation-based tests and correction for family-wise error rate. Multiple regression analysis was performed between MRI data and (i) neuropsychological results (ii) HIV infection characteristics. A linear discriminant analysis (LDA) based on MRI data was performed between MND+ and MND- patients and cross-validated with a leave-one-out test. %26lt;br%26gt;Results: Our data revealed loss of structural integrity and micro-oedema in MND+ compared to HC in the global white and cortical gray matter, as well as in the thalamus and basal ganglia. Multiple regression analysis showed a significant influence of sub-cortical nuclei alterations on the executive index of MND+ patients (p = 0.04 he and R-2 = 95.2). The LDA distinguished MND+ and MND- patients with a classification quality of 73% after cross-validation. %26lt;br%26gt;Conclusion: Our study shows micro-structural brain tissue alterations in MND+ patients under effective therapy and suggests that multi-contrast MRI at high field is a powerful approach to discriminate between HIV+ patients on cART with and without mild neurocognitive deficits.

• 出版日期2013-9-10