A Selective Thromboxane A(2) (TXA(2)) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid-Induced Lung Injury in Guinea Pigs

作者：Ishitsuka Yoichi^*; Moriuchi Hiroshi; Isohama Yoichiro; Tokunaga Hidehiro; Hatamoto Keita; Kurita Sumika; Irikura Mitsuru; Iyama Ken ichi; Irie Tetsumi

来源：Journal of Pharmacological Sciences, 2009, 111(2): 211-215.

DOI：10.1254/jphs.09128SC

• ozagrel
• oleic acid
• lung injury

This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.

• 出版日期2009-10