Acute intraperitoneal administration of taurine decreases the glycemia and reduces food intake in type 1 diabetic rats

作者：Gomez Rosane^*; Caletti Greice; Arbo Bruno Dutra; Hoefel Ana Lucia; Schneider Ricardo Jr; Hansen Alana Witt; Pulcinelli Rianne Remus; Freese Luana; Bandiera Solange; Kucharsk Luiz Carlos; Tanhauser Barros Helena Maria

来源：Biomedicine & Pharmacotherapy, 2018, 103: 1028-1034.

DOI：10.1016/j.biopha.2018.04.131

• Amino acid
• Glucagon
• Glycogen
• Insulin
• Palatable food
• Streptozotocin

Taurine, an amino acid with antioxidant and osmoregulatory properties, has been studied for its possible antidiabetic properties in type 1 and type 2 diabetic animals. In type 2 diabetic mice, taurine decreases blood glucose through increased insulin secretion and insulin receptor sensitization. However, insulin is absent in type 1 diabetic individuals. The aim of this study was to evaluate the effects of taurine on parameters related to the energy balance that could explain the metabolic action of this amino acid in type 1 diabetic rats. Control and streptozotocin-induced diabetic rats received saline or taurine (100 mg/kg/day), intraperitoneally, for 30 days. Parameters such as palatable food intake, gastrointestinal transit rate, serum glucose, insulin, leptin, and glucagon levels were measured 60 min after the last taurine administration. Liver, kidneys, heart, and retroperitoneal fat were dissected and weighted. Glycogen levels were measured in the liver and soleus muscle. Our results showed that acute taurine administration decreased glycemia. It also decreased food intake in diabetic rats, without affecting other metabolic parameters. Altogether, our results suggest that in type 1 diabetic rats, taurine decreases blood glucose by a non-insulin-dependent mechanism. Due to the safety profile of taurine, and its effect on glycemia, this amino acid may help to design new drugs to add benefit to insulin therapy in type 1 diabetic individuals.

• 出版日期2018-7