Determination of Esomeprazole on an Electropolymerized L-arginine and beta-cyclodextrin Modified Screen Printed Carbon Electrode

作者：Radi Abd Elgawad^*; Abd El Ghany Nadia; Wahdan Tarek

来源：Electroanalysis, 2016, 28(5): 1112-1118.

DOI：10.1002/elan.201501074

• L-arginine
• beta-cyclodextrin
• Esomeprazole
• Cyclic voltammetry
• Differential pulse voltammetry
• Electrochemical impedance spectroscopy

The formation of an inclusion complex of the proton-pump inhibitor (PPI) drug esomeprazole (ESO) with beta-cyclodextrin (beta-CD) has been investigated and proven by cyclic voltammetry (CV). The formation constant of the complex was determined. Thereafter, an electropolymerized beta-CD and L-arginine (L-arg) modified screen printed carbon electrode (P-beta-CD-L-arg/SPCE) was developed for the determination of ESO using differential pulse adsorptive stripping voltammetry (DPAdSV). A significant enhancement of the peak current was observed when applying an accumulation step due to the effect of adsorption. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) further indicated that the polymer of beta-CD and L-arg efficiently improved the electron transfer kinetic between analyte and electrode surface. Under the optimized conditions, the oxidation peak current was linearly proportional to the concentration of the drug in the range of 1.0 x 10(-8) to 1.0 x 10(-5) M. The DPAdSV method was successfully used to determine the concentrations of the drug in spiked human serum samples.

• 出版日期2016-5