Association of Biomarkers with Atherosclerosis and Risk for Coronary Artery Disease in Patients with HIV

作者：Brandao de Arruda Falcao Maria da Conceicao; Zirpoli Josefina Claudia; de Albuquerque Valeria Maria; Markman Filho Brivaldo; Moura de Araujo Nelson Antonio; Falcao Creso Abreu; Miranda Filho Democrito de Barros; de Arraes Ximenes Ricardo Alencar; Militao de Albuquerque Maria de Fatima; Lacerda Heloisa Ramos^*

来源：Arquivos Brasileiros de Cardiologia, 2012, 99(5): 971-978.

• Atherosclerosis
• risk factors
• coronary disease
• HIV

Background: The massive use of Highly-Active Antiretroviral Therapy (HAART) in individuals with human immunodeficiency virus (HIV) coincided with an increase in cardiovascular disease, a major cause of morbidity and mortality in this group. %26lt;br%26gt;Objective: To determine the frequency of carotid atherosclerosis and the association between biomarker levels and carotid intimal-medial thickening in HIV-positive individuals treated for HIV at referral centers in Pernambuco. %26lt;br%26gt;Methods: This was a cross-sectional study of 122 HIV-positive patients. Subclinical carotid atherosclerosis was considered with the presence of increased intimal-medial thickness of the common carotid artery %26gt; 0.8 mm or plaques in the carotid ultrasound. The following inflammatory biomarkers were analyzed: IL6, IL1-beta, TNF-alpha, high-sensitivity CRP, sVCAM-1 and sICAM-1. %26lt;br%26gt;Results: Of the 122 patients analyzed, most were men (60.7%) aged %26gt; 40 years (57.4%) receiving HAART (81.1%). The prevalence of atherosclerosis was 42.6% (52 cases). Patients older than 40 years and intermediate or high Framingham score were more likely to develop atherosclerosis at the univariate analysis. Age older than 40 years (OR = 6.57, 95%CI: 2.66 to 16.2, p = 0.000), male gender (OR = 2.76, 95%CI: 1.12 to 6.79, p = 0.027) and presence of syndrome metabolic (OR = 2.27, 95%CI: 0.94 to 5.50, p = 0.070) were associated with atherosclerosis at the multivariate analysis. Elevated levels of inflammatory cytokines and adhesion molecules were not associated with the presence of atherosclerosis. %26lt;br%26gt;Conclusion: There was no association between inflammatory biomarkers, adhesion molecules and presence of carotid atherosclerosis. However, a higher chance of subclinical atherosclerosis was observed in men, those older than 40 years, with intermediate / high Framingham score or metabolic syndrome. (Arq Bras Cardiol 2012;99(5):971-978)

• 出版日期2012-11