A novel fortified blended flour, corn-soy blend %26quot;plus-plus,%26quot; is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children

作者：LaGrone Lacey N; Trehan Indi; Meuli Gus J; Wang Richard J; Thakwalakwa Chrissie; Maleta Kenneth; Manary Mark J^*

来源：American Journal of Clinical Nutrition, 2012, 95(1): 212-219.

DOI：10.3945/ajcn.111.022525

Background: Children with moderate acute malnutrition (MAM) are often treated with fortified blended flours, most commonly a corn-soy blend (CSB). However, recovery rates remain %26lt;75%, lower than the rate achieved with peanut paste-based ready-to-use supplementary foods (RUSFs). To bridge this gap, a novel CSB recipe fortified with oil and dry skim milk, %26quot;CSB++,%26quot; has been developed. %26lt;br%26gt;Objective: In this trial we compared CSB++ with - RUSF products for the treatment of MAM to test the hypothesis that the recovery rate achieved with CSB++ will not be %26gt;5% worse than that achieved with either RUSF. %26lt;br%26gt;Design: We conducted a prospective, randomized, investigator-blinded, controlled noninferiority trial involving rural Malawian children aged 6-59 mo with MAM. Children received 75 kcal CSB++ . kg(-1) . d(-1), locally produced soy RUSF, or an imported soy/whey RUSF for %26lt;= 12 wk. %26lt;br%26gt;Results: The recovery rate for CSB++ (n = 763 of 888; 85.9%) was similar to that for soy RUSF (795 of 806, 87.7%; risk difference: -1.82%; 95% CI: -4.95%, 1.30%) and soy/whey RUSF (807 of 918, 87.9%; risk difference: -1.99%; 95% CI: -5.10%, 1.13%). On average, children who received CSB++ required 2 d longer to recover, and the rate of weight gain was less than that with either RUSF, although height gain was the same among all 3 foods studied. %26lt;br%26gt;Conclusions: A novel, locally produced, fortified blended flour (CSB++) was not inferior to a locally produced soy RUSF and an imported soy/whey RUSF in facilitating recovery from MAM. The recovery rate observed for CSB++ was higher than that for any other fortified blended flour tested previously. This trial is registered at clinical-trials.gov as NCT00998517. Am J Clin Nutr 2012;95:212 9

• 出版日期2012-1