Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

作者：Forbes Josephine M; Sourris Karly C^*; de Courten Maximilian P J; Dougherty Sonia L; Chand Vibhasha; Lyons Jasmine G; Bertovic David; Coughlan Melinda T; Schlaich Markus P; Soldatos Georgia; Cooper Mark E; Straznicky Nora E; Kingwell Bronwyn A; de Courten Barbora

来源：Amino Acids, 2014, 46(2): 321-326.

DOI：10.1007/s00726-013-1542-9

• Insulin secretion
• Insulin sensitivity
• Central obesity
• Type 2 diabetes

It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 +/- A 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p < 0.05) and lower 2-h glucose concentrations during OGTT (r = -0.31; p < 0.05). In addition, fasting (r = -0.36; p < 0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms (r = -0.39; p < 0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.

• 出版日期2014-2