Albendazole versus metronidazole in the treatment of adult giardiasis: a randomized, double-blind, clinical trial

作者：Canete Roberto^*; Rodriguez Pablo; Mesa Lumey; Brito Katia; Prior Ada; Guilhem Dirce; Novaes M R C G

来源：Current Medical Research and Opinion, 2012, 28(1): 149-154.

DOI：10.1185/03007995.2011.637915

• Albendazole
• Benzimidazoles
• Giardia duodenalis
• Metronidazole

Background: %26lt;br%26gt;Albendazole (ABZ) is a benzimidazole carbamate compound currently in use for human medical practice against enterobiasis and soil-transmitted helminthiasis (STH); However, its spectrum of activity is broad and goes beyond these infections. %26lt;br%26gt;Objective: %26lt;br%26gt;This study compares the efficacy and safety of ABZ versus metronidazole (MTZ) in human giardiasis. %26lt;br%26gt;Research design and methods: %26lt;br%26gt;A randomized, double-blind, clinical trial was carried out at the Centre of Hygiene, Epidemiology and Microbiology in Matanzas City, Cuba. Adult patients with confirmed symptomatic G. duodenalis mono-infection were randomly assigned to receive either ABZ [400 mg daily (n = 75)] or MTZ [250 mg t.i.d. (n = 75)], both for 5 days. Follow-up fecal samples were obtained at 3, 5, 7 days after treatment end. %26lt;br%26gt;Results: %26lt;br%26gt;The efficacy was similar for both treatment groups: ABZ (82.6%) and MTZ (85.3%); p%26gt;0.05. Side-effects including bitter taste, headache, vomiting and dizziness were significantly higher in the MTZ group. Abdominal pain was significantly higher in ABZ group. %26lt;br%26gt;Conclusion: %26lt;br%26gt;ABZ was found as effective as MTZ in the treatment of G. duodenalis infections in adult patients from Cuba and could be a useful drug in areas where co-infection with STH infections is common.

• 出版日期2012-1