Determination of Malignant and Invasive Predictors in Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Suggested Scoring Formula

作者：Hwang Dae Wook; Jang Jin Young^*; Lim Chang Sup; Lee Seung Eun; Yoon Yoo Seok; Ahn Young Joon; Han Ho Seong; Kim Sun Whe; Kim Sang Geol; Yun Young Kook; Han Seong Sik; Park Sang Jae; Lim Tae Jin; Kang Koo Jung; Sim Mun Sup; Choi Seong Ho; Heo Jin Seok; Choi Dong Wook; Hur Kyung Yul; Lee Dong Shik; Yun Sung Su; Kim Hong Jin; Cho Chul Kyoon; Kim Hyun Jong; Yu Hee Chul; Cho Baik Hwan; Song In Sang

来源：Journal of Korean Medical Science, 2011, 26(6): 740-746.

DOI：10.3346/jkms.2011.26.6.740

• Branch Duct Type Intraductal Papillary Mucinous Neoplasm (IPMN)
• Cyst Size
• Mural Nodule
• CEA
• Malignancy
• Invasive Carcinoma

Prediction of malignancy or invasiveness of branch duct type intraductal papillary mucinous neoplasm (Br-IPMN) is difficult, and proper treatment strategy has not been well established. The authors investigated the characteristics of Br-IPMN and explored its malignancy or invasiveness predicting factors to suggest a scoring formula for predicting pathologic results. From 1994 to 2008, 237 patients who were diagnosed as Br-IPMN at 11 tertiary referral centers in Korea were retrospectively reviewed. The patients' mean age was 63.1 +/- 9.2 yr. One hundred ninty-eight (83.5%) patients had nonmalignant IPMN (81 adenoma, 117 borderline atypia), and 39 (16.5%) had malignant IPMN (13 carcinoma in situ, 26 invasive carcinoma). Cyst size and mural nodule were malignancy determining factors by multivariate analysis. Elevated CEA, cyst size and mural nodule were factors determining invasiveness by multivariate analysis. Using the regression coefficient for significant predictors on multivariate analysis, we constructed a malignancy-predicting scoring formula: 22.4 (mural nodule [0 or 1]) + 0.5 (cyst size [mm]). In invasive IPMN, the formula was expressed as invasiveness-predicting score = 36.6 (mural nodule [0 or 1]) + 32.2 (elevated serum CEA [0 or 1]) + 0.6 (cyst size [mm]). Here we present a scoring formula for prediction of malignancy or invasiveness of Br-IPMN which can be used to determine a proper treatment strategy.

• 出版日期2011-6