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摘要
A remarkably simple, mild and efficient approach for carbon-carbon bond cleavage of beta-keto amides using N-bromobutanimide (NBS) as the bromine source and acetic acid as the catalyst to construct alpha-dibromosubstituted arylamides is achieved. Moreover, tandem carbon-bromine bond formation, followed by protonation of carbonyl and cleavage of C-C bond in one pot has also been demonstrated. All the reactions were carried out under extremely mild conditions and provided almost quantitative yields of the products.
- 出版日期2015-2
- 单位广东石油化工学院
