Normal physical activity obliterates the deleterious effects of a high-caloric intake

作者：Krogh Madsen Rikke^*; Pedersen Maria; Solomon Thomas P J; Knudsen Sine Haugaard; Hansen Louise Seier; Karstoft Kristian; Lehrskov Schmidt Louise; Pedersen Karin Kaereby; Thomsen Carsten; Holst Jens Juul; Pedersen Bente K

来源：Journal of Applied Physiology, 2014, 116(3): 231-239.

DOI：10.1152/japplphysiol.00155.2013

• physical inactivity
• high-caloric diet
• visceral obesity
• glucose metabolism
• cognitive function

A high-caloric intake combined with a sedentary lifestyle is an important player in the development of type 2 diabetes mellitus (T2DM). The present study was undertaken to examine if the level of physical activity has impact on the metabolic effects of a high-caloric (+2,000 kcal/day) intake. Therefore, healthy individuals on a high-caloric intake were randomized to either 10,000 or 1,500 steps/day for 14 days. Step number, total energy expenditure, dietary records, neuropsychological tests, maximal oxygen uptake (over dot (V)(O2max)), whole body dual-energy X-ray absorptiometry (DXA) and abdominal magnetic resonance imaging (MRI) scans, continuous glucose monitoring (CGM), and oral glucose tolerance tests (OGTT) with stable isotopes were performed before and after the intervention. Both study groups gained the same amount of body weight. However, the inactive group accumulated significantly more visceral fat compared with the active group. Following the 2-wk period, the inactive group also experienced a poorer glycemic control, increased endogenous glucose production, decreased hepatic insulin extraction, increased baseline plasma levels of total cholesterol and LDL, and a decreased cognitive function with regard to capacity of attention. In conclusion, we find evidence to support that habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.

• 出版日期2014-2