Disease Specific Biomarkers of Abdominal Aortic Aneurysms Detected by Surface Enhanced Laser Desorption Ionization Time of Flight Mass Spectrometry

作者：Ehsan S^*; Ball G; Choke E; Molyneux K M; London N J M; Herbert K E; Barratt J; Sayers R D; Bown M J

来源：European Journal of Vascular and Endovascular Surgery, 2012, 44(1): 52-54.

DOI：10.1016/j.ejvs.2012.04.018

• AAA
• Biomarkers
• Proteomics

Introduction: Biomarkers have the potential to improve the clinical management of patients with AAA. %26lt;br%26gt;Report: A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89. %26lt;br%26gt;Discussion: This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.

• 出版日期2012-7