Adenosine 5 '-Triphosphate-Sensitive Potassium Channel Activator Induces the Up-Regulation of Caveolin-1 Expression in a Rat Brain Tumor Model

作者：Gu, Yan-ting^*; Xue, Yi-xue; Zhang, Hua; Li, Yan; Liang, Xin-yuan

来源：Cellular and Molecular Neurobiology, 2011, 31(4): 629-634.

DOI：10.1007/s10571-011-9658-5

• Adenosine 5 '-triphosphate-sensitive potassium channel
• Glioma
• Reactive oxygen species
• Caveolin-1

This study was performed to determine whether minoxidil sulfate (MS), a selective Adenosine 5'-triphosphate-sensitive potassium channel (K (ATP) channel) activator, has an effect on the expression of caveolin-1 in the rat's brain tumor tissue. Using a rat brain glioma (C6) model, we found that the expression of caveolin-1 protein at tumor sites was greatly increased after intracarotid infusion of MS at a dose of 30 mu g/kg/min for 15, 30, and 60 min via Western blot analysis. And the peak value of the caveolin-1 expression was observed in rats with glioma after 15 min of MS perfusion, which was significantly attenuated by reactive oxygen species (ROS) scavenger (N-2-mercaptopropionyl glycine, MPG). In addition, MPG also significantly inhibited the increase of blood-brain tumor barrier (BTB) permeability which was induced by MS. This led to the conclusion that the MS-induced BTB permeability increase may be related to the accelerated formation of caveolin-1 protein, and could be mediated by ROS.

• 出版日期2011-5
• 单位中国医科大学; 沈阳药科大学