Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling

作者：Shen Li; Simmons Charles J; Sun Dianqing^*

来源：Tetrahedron Letters, 2012, 53(32): 4173-4178.

DOI：10.1016/j.tetlet.2012.05.142

• Microwave-assisted synthesis
• Macrocycle
• Diaryl ether
• Intramolecular
• Bimolecular
• Ullmann coupling

Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling.

• 出版日期2012-8-8