Multifunctional PS@CS@Au-Fe3O4-FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells

作者：Wang, Yeying; Liu, Xijian^*; Deng, Guoying; Wang, Qian; Zhang, Lijuan; Wang, Qiugen; Lu, Jie^*

来源：Journal of Materials Chemistry B, 2017, 5(22): 4221-4232.

DOI：10.1039/c7tb00642j

• MESOPOROUS SILICA NANOPARTICLES
• NEAR-INFRARED LIGHT
• ONE-POT SYNTHESIS
• IN-VIVO
• INDOCYANINE GREEN
• HEPATOCELLULAR-CARCINOMA
• GOLD NANOPARTICLES
• DRUG-DELIVERY
• FOLIC-ACID
• TUMOR

In this work, multifunctional polystyrene@chitosan@gold nanoparticles-Fe3O4 nanoparticles-folic acid/indocyanine green (PS@CS@Au-Fe3O4-FA/ICG) nanocomposites that can integrate diagnosis and therapy into one nanoplatform was fabricated. The constructed PS@CS@Au-Fe3O4-FA/ICG nanocomposites possessed excellent computed tomography, magnetic resonance and fluorescence imaging performances which could be used to diagnose tumor and monitor the nanocomposites' localization in vivo. Moreover, PS@CS@Au-Fe3O4-FA/ICG nanocomposites can be delivered in a targeted manner to cancer cells by folic acid in a receptor-mediated way, and tumor growth could be efficiently inhibited, even completely ablated, under NIR irradiation. That is, the constructed PS@CS@Au-Fe3O4-FA/ICG nanocomposites had great potential for computed tomography, magnetic resonance and fluorescence imaging performances, which could be used to diagnose tumors and to monitor local therapy and fluorescence imaging-guided targeted therapy of cancer cells using nanocomposites.

• 出版日期2017-6-14
• 单位上海工程技术大学; 上海交通大学