Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

作者：Krueger A Chris^*; Randolph John T; DeGoey David A; Donner Pamela L; Flentge Charles A; Hutchinson Douglas K; Liu Dachun; Motter Christopher E; Rockway Todd W; Wagner Rolf; Beno David W A; Koev Gennadiy; Lim Hock B; Beyer Jill M; Mondal Rubina; Liu Yaya; Kati Warren M; Longenecker Kenton L; Molla Akhteruzzaman; Stewart Kent D; Maring Clarence J

来源：Bioorganic & Medicinal Chemistry Letters, 2013, 23(12): 3487-3490.

DOI：10.1016/j.bmcl.2013.04.057

• Hepatitis C
• NS5B polymerase inhibitors
• Aryl uracil

The synthesis and structure-activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.

• 出版日期2013-6-15