Anti-Hu-associated Paraneoplastic Encephalomyelitis with Esophageal Small Cell Carcinoma

作者：Shirafuji Toshihiko^*; Kanda Fumio; Sekiguchi Kenji; Higuchi Masatsugu; Yokozaki Hiroshi; Tanaka Keiko; Takahashi Hitoshi; Toda Tatsushi

来源：Internal Medicine, 2012, 51(17): 2423-2427.

DOI：10.2169/internalmedicine.51.6884

• anti-Hu-associated paraneoplastic encephalomyelitis
• esophageal small cell carcinoma
• multiple lesions

A 63-year-old woman had anti-Hu-associated paraneoplastic encephalomyelitis (anti-Hu syndrome) caused by esophageal small cell carcinoma (SCC). The patient developed bilateral limbic encephalitis, followed by myelitis, brain stem encephalitis, and autonomic failure. Extensive examination demonstrated SCC of the abdominal lymph nodes that was retrospectively diagnosed as metastasis of esophageal SCC on autopsy. The neuropathological findings were characterized by widespread neuronal loss and gliosis in the central nervous system, as well as patchy loss of myelin and axons in the spinal nerve roots with perivascular lymphocytic infiltration. This is the first detailed clinical and neuropathological report of anti-Hu syndrome caused by esophageal SCC.

• 出版日期2012