Antidepressant-like effect of asiaticoside in mice

作者：Liang Xin; Huang Yan Ni; Chen Si Wei^*; Wang Wen Juan; Xu Na; Cui Shan; Liu Xing Hua; Zhang Hua; Liu Yue Nan; Liu Shuang; Yang Ming; Dong Yan

来源：Pharmacology Biochemistry and Behavior, 2008, 89(3): 444-449.

DOI：10.1016/j.pbb.2008.01.020

• asiaticoside
• clomipramine
• antidepressant
• mice
• splash test
• unpredictable chronic mild stress (CMS) model
• tail suspension test
• forced swimming test

In the present study, the potential antidepressant properties of asiaticoside were investigated in male mice in three tests-splash test in the unpredictable chronic mild stress (CMS) model, tail suspension test (TST), forced swimming test (FST)-with clomipramine being a positive control. In the splash test, asiaticoside (10 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly augmented the frequency of grooming behavior in stressed mice. In the tail suspension test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. In the forced swimming test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. These results suggest that asiaticoside may have antidepressant-like action.

• 出版日期2008-5
• 单位沈阳药科大学