Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine

作者：Fuchi Yasufumi; Obayashi Hideto; Sasaki Shigeki^*

来源：Molecules, 2015, 20(1): 1078-1087.

DOI：10.3390/molecules20011078

• oxidative damage
• oxidized nucleoside
• 8-oxoguanosine
• 8-nitroguanosine
• 8-thioguanosine

The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.

• 出版日期2015-1