Multicomponent Assembly Strategies for the Synthesis of Diverse Tetrahydroisoquinoline Scaffolds

作者:Granger Brett A; Kaneda Kyosuke; Martin Stephen F*
来源:Organic Letters, 2011, 13(17): 4542-4545.
DOI:10.1021/ol201739u

摘要

Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.

  • 出版日期2011-9-2