Differences in cancer stage, treatment and in-hospital mortality between patients with and without schizophrenia: retrospective matched-pair cohort study

作者：Ishikawa Hanako; Yasunaga Hideo^*; Matsui Hiroki; Fushimi Kiyohide; Kawakami Norito

来源：The British Journal of Psychiatry, 2016, 208(3): 239-244.

DOI：10.1192/bjp.bp.114.156265

Background
Healthcare access and outcomes in cancer patients with schizophrenia remain unclear.
Aims
To investigate the likelihood of early diagnosis and treatment in patients with schizophrenia who have cancer and their prognosis.
Method
A retrospective matched-pair cohort of gastrointestinal cancer patients was identified using a national in-patient database in Japan. Multivariable ordinal/binary logistic regressions was modelled to compare cancer stage at admission, invasive treatments and 30-day in-hospital mortality between patients with schizophrenia (n = 2495) and those without psychiatric disorders (n = 9980).
Results
The case group had a higher proportion of stage IV cancer (33.9% v. 18.1%), a lower proportion of invasive treatment (56.5% v. 70.2%, odds ratio (OR) = 0.77, 95% CI 0.69-0.85) and higher in-hospital mortality (4.2% v. 1.8%, OR = 1.35, 95% CI 1.04-1.75).
Conclusions
Patients with schizophrenia who had gastrointestinal cancer had more advanced cancer, a lower likelihood of invasive treatment and higher in-hospital mortality than those without psychiatric disorders.

• 出版日期2016-3