科研之友
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摘要
Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level. Results The mean serum level of sex hormone-binding globulin was increased in old-aged men (older than 40 years; mean 44.68 +/- 20.58 nmol/L), low diastolic blood pressure (<90mmHg; 43.76 +/- 20.50 nmol/L), waist-to-height ratio <0.5 (48.73 +/- 20.59 nmol/L), no education (52.36 +/- 22.91 nmol/L), farm occupation (43.58 +/- 20.60nmol/L), non-alcohol or former user (44.78i20.94 nmol/L) and long-term medication history (44.79 +/- 21.50 nmol/L). Factors independently associated with sex hormone binding globulin level on multiple regression were waist-to-height ratio (beta=11.84 [95% confidence interval -13.96,-9.721), age(beta=12.40 [9.63,15.17]) and diastolic blood pressure (beta=-5.07 [-7.44,2.711). Conclusions Central obesity has an independent inverse relation with serum level of sex hormone binding globulin among western Chinese men.
