Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome

作者：Oweira H; Landou I; Opelz G; Daniel V; Terness P; Schmidt J; Mehrabi A; Fusch G; Schefold J; Zidan A; Sadeghi M^*

来源：Transplant Immunology, 2018, 46: 42-48.

DOI：10.1016/j.trim.2017.12.003

• Tryptophan
• Kynurenine
• Kynurenic acid
• Phenylalanine
• Meld

The aim of the present study was to investigate association of serum amino (AA) acids and metabolites of AAs with post-transplant outcome in liver transplant recipients.
Eighty-nine patients with end-stage liver diseases and available pre- and early post-transplant serum were characterised as patients with (GI) and without one-year mortality (GII) and patients with and without early graft dysfunction (EAD). A panel of pre- and early post-transplant serum levels of AAs and early and metabolites of tryptophan were measured using tandem mass spectrometry.
Patient groups had significantly higher pm-transplant serum levels of phenylalanine, tryptophan, and tryptophan metabolites than healthy controls (for all p < 0.001). Pre-transplant serum levels of all these parameters were significantly higher in GI than in GII (for all p < 0.001). GI had a higher MELD score and re-transplantation number than GII (p <= 0.005 for both investigations). Serum bilirubin on day 5 and serum phenylalanine on day 10 post-transplant were associated parameters of mortality, whereas day 1post-transplant phenylalanine and kynurenine and female gender were associated parameters of EAD.
Our results indicate that pre- and early post-transplant levels of phenylalanine, tryptophan and metabolites of tryptophan are increased in patients and are associated with EAD and one-year mortality in liver transplant recipients.

• 出版日期2018-2