An Iron-Clad Role for Proteasomal Degradation

作者：Andrews Nancy C^*

来源：Cell Metabolism, 2011, 14(3): 281-282.

DOI：10.1016/j.cmet.2011.08.001

Iron homeostasis is essential for life and health. In this issue of Cell Metabolism, Moroishi and colleagues (2011) show that FBXL5, an iron sensor in an ubiquitin ligase complex, keeps cellular iron in balance by promoting the degradation of IRP2 in vivo.

• 出版日期2011-9-7