Absolute Configuration and Enantiodifferentiation of a Hemicryptophane Incorporating an Azaphosphatrane Moiety

作者：Payet Elina; Dimitrov Raytchev Pascal; Chatelet Bastien; Guy Laure; Grass Stephane; Lacour Jerome; Dutasta Jean Pierre^*; Martinez Alexandre

来源：Chirality, 2012, 24(12): 1077-1081.

DOI：10.1002/chir.22100

• hemicryptophane
• chiral separation
• absolute configuration
• chiroptical properties
• TRISPHAT
• chiral solvating agent

The hemicryptophane racemate (+/-)- was optically resolved by semipreparative HPLC on Chiralpak IC column. The absolute configuration of each isolated enantiomer was established from the analysis of their electronic circular dichroism spectra. Enantiodifferentiation of the chiral cationic cage (+/-)- was evidenced in solution using Delta TRISPHAT as chiral solvating agent, and the diastereomeric associations were observed in H-1 and P-31 NMR spectra. Chirality 24:10771081, 2012.

• 出版日期2012-12