Novel triphosphorylation polyurethane nanoparticles for blood-contacting biomaterials' coating

作者：Zhang, Jun; Sun, Zhijun; Zhu, Haomiao; Guo, Qiaochu; He, Chengai; Xia, Ao^*; Mo, Hong; Huang, Xiaohua^*; Shen, Jian

来源：Journal of Materials Chemistry B, 2016, 4(6): 1116-1121.

DOI：10.1039/c5tb01877c

• IN-VITRO
• SEGMENTED POLYURETHANE
• SURFACE
• COMPATIBILITY
• HEMOCOMPATIBILITY
• VIABILITY
• POLYMER
• MONOMER

Improving hemocompatibility of biomaterials and devices contacting the human blood has been the subject of intensive research. In this study, we synthesized a novel excellent blood compatible polyurethane/sodium triphosphate nanoparticle (PU/STPP). Characterization of polyurethane/sodium triphosphate (PU/STPP) nanoparticles was carried out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), nuclear magnetic resonance (NMR), and energy dispersive spectros-copy (EDS). Blood compatibility assessment of PU/STPP nanoparticles was performed by in vitro coagulation time, plasma clotting time, hemolysis rate, and red blood cell morphology tests. Cell compatibility evaluations of PU/STPP nanoparticles were obtained by MTT cell viability tests. The PU/STPP nanoparticles also were used to modify vascular prostheses with cosedimentation. Platelet adhesion tests showed that blood compatibility of vascular prostheses coated with PU/STPP nanoparticles is better than that of pure vascular prostheses.

• 出版日期2016
• 单位南京师范大学