Pulmonary pleomorphic carcinoma with few PD-1-positive immune cells and regulatory T cells that showed a complete response to nivolumab

作者：Okamura Kazuaki; Fukuda Yuichi; Soda Hiroshi^*; Ogawara Daiki; Iwasaki Keisuke; Fuchi Shinichiro; Suyama Takayuki; Yoshida Masataka; Harada Tatsuhiko; Fukuda Minoru; Mukae Hiroshi

来源：Thoracic Cancer, 2018, 9(1): 193-196.

DOI：10.1111/1759-7714.12557

• Immunotherapy
• programmed death-1
• regulatory T cells

Pulmonary pleomorphic carcinoma has been shown to respond remarkably to PD-1 inhibitors; however, the biomarkers for this therapy have not been fully proven. We report a case of pulmonary pleomorphic carcinoma with overexpressed PD-L1, in which a complete response to nivolumab was sustained for >14months. Immunohistochemical analysis revealed few PD-1(+) immune cells and regulatory T cells in the tumor, in addition to predominant infiltration of CD8(+) cells and macrophages. Our findings suggest that the presence of a small number of PD-1(+) immune cells and regulatory T cells should be investigated as candidate therapeutic biomarkers.

• 出版日期2018-1