Pulmonary Mucormycosis due to Lichtheimia ramosa in a Patient with HIV Infection

作者：Kutlu Murat^*; Ergin Cagri; Bir Ferda; Hilmioglu Polat Suleyha; Gumral Ramazan; Necan Ceyda; Kocyigit Ali; Sayin Kutlu Selda

来源：Mycopathologia, 2014, 178(1-2): 111-115.

DOI：10.1007/s11046-014-9761-5

• HIV infection
• Pulmonary mucormycosis
• Lichtheimia ramosa

Mucormycosis is increasingly common in patients with risk factors such as diabetes mellitus, neutropenia, and corticosteroid therapy. However, mucormycosis seems to be less common in patients with human immunodeficiency virus (HIV) infection compared to patients with other risk factors. Despite their lower virulence, Lichtheimia species should be regarded as emerging pathogens among Mucoralean fungi. We report a fatal case of pulmonary mucormycosis due to Lichtheimia ramosa in a 52-year-old man with an end-stage HIV infection. He had a cachectic appearance and his CD4 count was 8 cells/mm(3). The fungal infection was diagnosed based on a positive sputum culture with histopathologic confirmation. The fungus was resistant to caspofungin, anidulafungin, and voriconazole [minimum inhibitory concentration (MCI) %26gt; 32 A mu g/ml], whereas the E test MIC values of itraconazole, posaconazole, and amphotericin B were 0.38, 0.38, and 0.5 A mu g/ml, respectively. Although intravenous drug use is the main risk factor for the development of mucormycosis in HIV-infected patients, it may also develop in patients with low CD4 count, opportunistic infections and/or additional diseases, such as Kaposi%26apos;s sarcoma or severe immunodeficiency, as in our case.

• 出版日期2014-8
• 单位中国人民解放军军事医学科学院