Molecular networks in respiratory epithelium carcinomas

作者：Pallis Athanasios G; Karamouzis Michalis V; Konstantinopoulos Panagiotis A; Papavassiliou Athanasios G^*

来源：Cancer Letters, 2010, 295(1): 1-6.

DOI：10.1016/j.canlet.2010.03.014

• Respiratory epithelium carcinomas
• EGFR
• Ras
• Raf
• MAPK
• PI3K
• Akt
• JAK
• STAT
• PLC
• PKC

Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellular networks that participate in respiratory epithelium carcinogenesis have further elucidated the role of a variety of molecules that represent attractive targets for novel therapeutic strategies. The aim of this review is to explore the potential therapeutic opportunities of the manipulation of these pathways.

• 出版日期2010-9-1