Phytochemical characterization and biological activity of secondary metabolites from three Limonium species

作者：Gadetskaya Anastassiya V; Mohamed Shaymaa M; Tarawneh Amer H; Mohamed Nesma M; Ma Guoyi; Ponomarev Boris N; Zhusupova Galiya E; Cantrell Charles L; Cutler Stephen J; Ross Samir A^*

来源：Medicinal Chemistry Research, 2017, 26(11): 2743-2750.

DOI：10.1007/s00044-017-1973-z

• Plumbaginaceae
• Limonium
• Antifungal
• Antimalarial
• Antitrypanosomal

The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R, 3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2-21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1-21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14 showed a significant activity against Trypanosoma brucei.

• 出版日期2017-11