Wheat gluten hydrolysate alters the progress of hepatic pathology induced by prolonged carbon tetrachloride administration in rat

作者：Suzuki Yoshio; Asano Mariko; Sato Kenji; Asami Makiko; Sakamoto Akika; Tsutsumi Masahiro; Kido Yasuhiro^*

来源：Biomedical Research-India, 2011, 22(4).

• Glutamine
• cirrhosis
• carbon tetrachloride
• wheat gluten hydrolysate

Wheat gluten hydrolysate (WGH) has been reported to mitigate chronic hepatitis in some patients. We aimed to reproduce and examine this phenomenon in a rat experimental model. Male Sprague-Dawley rats were injected with carbon tetrachloride twice a week for 25 weeks, and 3 weeks later WGH was added to the feed (none, 4%, and 8%) for the remaining 22 weeks. Transition of serum transaminases showed a temporary decrease in aspartate aminotransferase (AST) and a delay in the peaking of alanine aminotransferase (ALT) in the WGH groups. Macroscopically, at the end of the 25 weeks, the progress of cirrhosis was milder in the WGH groups, as indicated by less ascites fluid and the fewer tubercle formations. Histological and immunohistochemical analyses of the liver revealed fewer collagen fibers and less alpha-smooth muscle actin (SMA) in the 8% WGH group. The ethanol-soluble extract of liver tissue showed plasmin inhibiting activity in the 8% WGH group. The observed modification of the transition of serum transaminases during chronic CCl4 challenge supports the possibility that WGH mitigates chronic hepatitis, and the liver manifestations after 25 weeks of CCl4 treatment indicate that WGH ingestion alters the progress of cirrhosis.

• 出版日期2011-12