BODY MASS INDEX AFFECTS THE DIAGNOSIS AND PROGRESSION OF PROSTATE CANCER IN HISPANICS

作者：Negron Rosa; Vasquez Andrea; Nieves Mariely; Guerrios Lourdes; Irizarry Ramirez Margarita^*

来源：Ethnicity & Disease, 2010, 20(1): 168-172.

• PSA
• Prostate Cancer
• Hispanics
• BMI

Introduction: The occurrence of lower prostate-specific antigen (PSA) levels in overweight White and African American men has been studied, but there is no data regarding Hispanics, which have a higher mortality rate from Prostate Cancer (PCa) than Whites. The objective of this study was to investigate if being overweight could affect both the sensitivity of the PSA as a diagnostic tool and the progression of PCa in this group.
Methods: Retrospective study of records from 400 patients that underwent testing for PCa during 2005 and 400 patients under treatment for PCa from 2003-2005 at the urology clinics of the Veterans Administration Caribbean Healthcare System. Accrued data included body mass index (BMI), age, PSA levels, biopsy results, and cancer status after treatment.
Results: In men, with normal age adjusted PSA levels, overweight and obese men had 35.38% and 38.13%, respectively, positive biopsies while men with normal BMI had 26.15%. In addition, 73.84% of overweight men over 61 years old with normal PSA were positive for prostate cancer. There is a statistically significant decrease in PSA sensitivity from 71.7 (95% CI:58.6-82.5) in men with normal BMI to 55.4 (95% CI:41.5-68.7) in obese men (P=.015). In multivariate analysis, patients with a BMI over 25 kg/m(2) had a 2.63 (CI 95%: 1.23-5.64) fold higher risk of metastases than those with normal BMI.
Conclusions: In overweight Hispanic men the PSA level is a less sensitive marker for PCa and those individuals with higher BMI have higher prevalence of metastatic disease. (Ethn Dis. 2010;20[Suppl 1]:S1-168-S1-172)

• 出版日期2010