Gold-Catalyzed Synthesis of 2-Deoxy Glycosides Using S-But-3-ynyl Thioglycoside Donors

作者：Adhikari Surya; Baryal Kedar N; Zhu Danyang; Li Xiaohua; Zhu Jianglong^*

来源：ACS Catalysis, 2013, 3(1): 57-60.

DOI：10.1021/cs300670k

• gold
• homogeneous catalysis
• alkyne
• glycosylation
• 2-deoxy glycosides

A mild and atom-economic gold(I)-catalyzed glycosylation for stereoselective synthesis of 2-deoxy alpha-glycosides using bench-stable 2-deoxy S-But-3-ynyl thioglycoside donors has been described. Under optimal conditions, 2-deoxy and 2,6-dideoxy thioglycoside donors were able to react with a variety of primary, secondary, and tertiary alcohol acceptors to afford alpha-selective glycosides in good to excellent yields.

• 出版日期2013-1